is beehaw related to lemmy?

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Cake day: June 8th, 2023

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  • Like you said, there’s a metric ton of steps involved in the overall process, and our understanding of each of these ‘levels’ of organization varies quite a bit. Closest to my personal expertise is the sub-cellular and cellular level, for which I would refer you books or papers in developmental biology, developmental genetics, and epigenetics. I can give you a couple bloopers to get you excited though:

    When it comes to deciding where different organs will form (again, from a sub-cellular level), it essentially starts from a concentration gradient of certain proteins/chemicals inside the zygotic cell. This gradient then determines the level of activation of other proteins, each level then leading to different biochemical cascades which, once more cells have formed from the zygote, determine which organ systems will come from them. Messing around with this concentration gradient can, thus, dramatically affect an organism’s development, leading to, for example, a body with just ‘left’ organs on both halves, just ‘top’ organs on both halves, missing an entire organ system (like circulatory system and heart) and so on.

    A more or less similar process occurs to determine the shape of organs. As a simple example, when some animals with regenerative capabilities (like axolotls) lose a limb, they are able to regrow the limb to the exact same length as before. Turns out, each cell on the periphery of their limb has a certain concentration of receptor proteins on its surface, which acts as a molecular ‘signature’ of that cell’s position in the limb. These signatures provide information on how far to grow the limb for regeneration, and some chemicals, lile retinol, can even override these signatures and fool the organism’s body into regrowing the limb from scratch on top of the place of regeneration.

    I hope these examples give you an introduction to the mechanisms involved. There’s obviously a lot more involved, so I would again highly recommend textbooks and research papers if you’re interested.



















  • Holy shit dude, that was actually very helpful! I’ll need a few more go-throughs to fully grasp every piece here, but thanks a ton for writing it so precisely.

    Based on this though, is there no way to have port-forwarding except setting it up explicitly in my router? I ask this because 1) in my personal setup, I’ll be switching between wifi and mobile data quite often, and 2) I may end up on an institutional wifi after some time, in which case I won’t have access to the router