I have been using it for the last 3 months to expose services from my home internet (plex, wireguard, etc.) through a VPS and I’m pretty happy with it. It’s relatively simple to set up, I haven’t had any outages so far, and it’s nice that it supports UDP port forwarding as well as TCP (for wireguard).
Computational protein engineer here. Pretty good explanation. I wanted to add that just because we know that a protein’s behavior changes depending on pH, it is still interesting to see what atom-level changes to the 3D structure are caused by the pH shift (e.g. so that we can better predict those changes on other proteins).